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1

Opioid Receptor Three-Dimensional Structures from Distance Geometry Calculations with Hydrogen Bonding Constraints

Pogozheva, Irina D., Lomize, Andrei L., Mosberg, Henry I.

Journal:

Biophysical Journal

Year:

1998

Language:

english

File:

PDF, 759 KB

english, 1998

2

Complex of an Active μ-Opioid Receptor with a Cyclic Peptide Agonist Modeled from Experimental Constraints †

Fowler, Carol B., Pogozheva, Irina D., Lomize, Andrei L., LeVine, Harry, Mosberg, Henry I.

Journal:

Year:

2004

Language:

english

File:

PDF, 627 KB

english, 2004

3

Further Optimization and Evaluation of Bioavailable, Mixed-Efficacy μ-Opioid Receptor (MOR) Agonists/δ-Opioid Receptor (DOR) Antagonists: Balancing MOR and DOR Affinities

Harland, Aubrie A., Yeomans, Larisa, Griggs, Nicholas W., Anand, Jessica P., Pogozheva, Irina D., Jutkiewicz, Emily M., Traynor, John R., Mosberg, Henry I.

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 2.14 MB

english, 2015

4

In Vivo Effects of μ Opioid Receptor Agonist/δ Opioid Receptor Antagonist Peptidomimetics Following Acute and Repeated Administration

Anand, Jessica P, Kochan, Kelsey E, Nastase, Anthony F, Montgomery, Deanna, Griggs, Nicholas W, Traynor, John R, Mosberg, Henry I, Jutkiewicz, Emily M

Journal:

British Journal of Pharmacology

Year:

2018

Language:

english

File:

PDF, 1.16 MB

english, 2018

5

Prediction of protein structure: The problem of fold multiplicity

Andrei L. Lomize, Irina D. Pogozheva, Henry I. Mosberg

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1999

Language:

english

File:

PDF, 154 KB

english, 1999

6

Development of a model for the δ-opioid receptor pharmacophore: 3. Comparison of the cyclic tetrapeptide Tyr-c[D-Cys-Phe-D-Pen] OH with other conformationally constrained δ-receptor selective ligands

Andrei L. Lomize, Irina D. Pogozheva, Henry I. Mosberg

Journal:

Year:

1996

Language:

english

File:

PDF, 1.03 MB

english, 1996

7

Development of a model for the δ-opioid receptor pharmacophore. 4. Residue 3 dehydrophenylalanine analogues of Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13) confirm required gauche orientation of aromatic side chain

Henry I. Mosberg, Rajesh K. Dua, Irina D. Pogozheva, Andrei L. Lomize

Journal:

Year:

1996

Language:

english

File:

PDF, 758 KB

english, 1996

8

Thermodynamic model of secondary structure for α-helical peptides and proteins

Andrei L. Lomize, Henry I. Mosberg

Journal:

Year:

1997

Language:

english

File:

PDF, 272 KB

english, 1997

9

Complementarity of δ opioid ligand pharmacophore and receptor models

Henry I. Mosberg

Journal:

Year:

1999

Language:

english

File:

PDF, 426 KB

english, 1999

10

Long-range spin–spin coupling as an aid for the assignment of aromatic residues in peptide 1H-nmr spectra

Henry I. Mosberg

Journal:

Year:

1982

Language:

english

File:

PDF, 209 KB

english, 1982

11

Conformational and dynamic considerations in the design of peptide hormone analogs

Victor J. Hruby, Henry I. Mosberg, Tomi K. Sawyer, James J. Knittel, Todd W. Rockway, James Ormberg, Paul Darman, W. Y. Chan, Mac E. Hadley

Journal:

Year:

1983

Language:

english

File:

PDF, 812 KB

english, 1983

12

Synthesis of deuterium labelled penicillamine and its use for the assignment of the 1H NMR spectra of two cyclic enkephalin analogs

Henry I. Mosberg, John R. Omnaas, Kondareddiar Ramalingam, Ronald W. Woodard

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

1987

Language:

english

File:

PDF, 325 KB

english, 1987

13

Utilization of peptide carrier system to improve intestinal absorption: Targeting prolidase as a prodrug-converting enzyme

Jane P.-F. Bai, Ming Hu, P. Subramanian, Henry I. Mosberg, Gordon L. Amidon

Journal:

Journal of Pharmaceutical Sciences

Year:

1992

Language:

english

File:

PDF, 410 KB

english, 1992

14

Specifically deuterated l-malate as an NMR probe of the aspartate transcarbamylase catalytic site

Henry I Mosberg, Paul G Schmidt, Sally S Seaver

Journal:

Journal of Magnetic Resonance (1969)

Year:

1969

Language:

english

File:

PDF, 428 KB

english, 1969

15

Synthesis of a novel series of topographically constrained amino acids: Benzo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids

Chenguang Wang, Henry I. Mosberg

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 149 KB

english, 1995

16

1H NMR of succinate binding to aspartate transcarbamylase a comparison of results in D2O and H2O

Henry I. Mosberg, Carol B. Beard, Paul G. Schmidt

Journal:

Biophysical Chemistry

Year:

1976

Language:

english

File:

PDF, 849 KB

english, 1976

17

A high affinity, mu-opioid receptor-selective enkephalin analogue lacking an N-terminal tyrosine

Henry I. Mosberg, Jeffrey C. Ho, Katarzyna Sobczyk-Kojiro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 207 KB

english, 1998

18

Design of a high affinity peptidomimetic opioid agonist from peptide pharmacophore models

Chenguang Wang, Iain J. McFadyen, John R. Traynor, Henry I. Mosberg

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 205 KB

english, 1998

19

Key Residues Defining the μ-Opioid Receptor Binding Pocket: A Site-Directed Mutagenesis Study

Alfred Mansour, Larry P. Taylor, Jeffrey L. Fine, Robert C. Thompson, Mary T. Hoversten, Henry I. Mosberg, Stanley J. Watson, Huda Akil

Journal:

Journal of Neurochemistry

Year:

1997

Language:

english

File:

PDF, 1.07 MB

english, 1997

20

A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screen

Rebecca A Roof, David L Roman, Samuel T Clements, Katarzyna Sobczyk-Kojiro, Levi L Blazer, Shodai Ota, Henry I Mosberg, Richard R Neubig

Journal:

BMC Pharmacology

Year:

2009

Language:

english

File:

PDF, 1.20 MB

english, 2009

21

The role of hydrophobic interactions in positioning of peripheral proteins in membranes

Andrei L Lomize, Irina D Pogozheva, Mikhail A Lomize, Henry I Mosberg

Journal:

BMC Structural Biology

Year:

2007

Language:

english

File:

PDF, 6.72 MB

english, 2007

22

Pharmacophore elements of the TIPP class of delta opioid receptor antagonists

Henry I. Mosberg, John R. Omnaas, Katarzyna Sobczyk-Kojiro, Raj Dua, Jeffrey C. Ho, Wenli Ma, Paula Bush, Carol Mousigian, Andrei Lomize

Journal:

International Journal of Peptide Research and Therapeutics

Year:

1994

Language:

english

File:

PDF, 291 KB

english, 1994

23

Synthesis of 6- or 7-substituted 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids

Wenli Ma, Henry I. Mosberg

Journal:

International Journal of Peptide Research and Therapeutics

Year:

1999

Language:

english

File:

PDF, 390 KB

english, 1999

24

Molecular Mechanism of the Constitutive Activation of the L250Q Human Melanocortin-4 Receptor Polymorphism

Bettina Proneth, Zhimin Xiang, Irina D. Pogozheva, Sally A. Litherland, Oleg S. Gorbatyuk, Amanda M. Shaw, William J. Millard, Henry I. Mosberg, Carrie Haskell-Luevano

Journal:

Chemical Biology & Drug Design

Year:

2006

Language:

english

File:

PDF, 959 KB

english, 2006

25

Mechanism of Action and Structural Requirements of Constrained Peptide Inhibitors of RGS Proteins

Rebecca A. Roof, Yafei Jin, David L. Roman, Roger K. Sunahara, Masaru Ishii, Henry I. Mosberg, Richard R. Neubig

Journal:

Chemical Biology & Drug Design

Year:

2006

Language:

english

File:

PDF, 365 KB

english, 2006

26

Synthesis of Novel Peptide Inhibitors of Thrombin-induced Platelet Activation

Fernanda M. Burke, Mark Warnock, Alvin H. Schmaier, Henry I. Mosberg

Journal:

Chemical Biology & Drug Design

Year:

2006

Language:

english

File:

PDF, 63 KB

english, 2006

27

Novel Peptide Ligands of RGS4 from a Focused One-Bead, One-Compound Library

Rebecca A. Roof, Katarzyna Sobczyk-Kojiro, Anjanette J. Turbiak, David L. Roman, Irina D. Pogozheva, Levi L. Blazer, Richard R. Neubig, Henry I. Mosberg

Journal:

Chemical Biology & Drug Design

Year:

2008

Language:

english

File:

PDF, 369 KB

english, 2008

28

Structure-Based Design of Residue 1 Analogs of the Direct Thrombin Inhibitor Pentapeptide FM 19

Elizabeth A. Girnys, Katarzyna Sobczyk-Kojiro, Henry I. Mosberg

Journal:

Chemical Biology & Drug Design

Year:

2010

Language:

english

File:

PDF, 167 KB

english, 2010

29

Structural organization of G-protein-coupled receptors

Andrei L. Lomize, Irina D. Pogozheva, Henry I. Mosberg

Journal:

Journal of Computer-Aided Molecular Design

Year:

1999

Language:

english

File:

PDF, 659 KB

english, 1999

30

Synthesis of 6- or 7-substituted 1,2,3,4-tetrahydroisoquinoline- 3-carboxylic acids

Wenli Ma, Henry I. Mosberg

Journal:

International Journal of Peptide Research and Therapeutics

Year:

1999

Language:

english

File:

PDF, 49 KB

english, 1999

31

Structural Requirements for the Intestinal Mucosal-Cell Peptide Transporter: The Need for N-Terminal α-Amino Group

Pel-Fan Bai, Pullachipatti Subramanian, Henry I. Mosberg, Gordon L. Amidon

Journal:

Pharmaceutical Research

Year:

1991

File:

PDF, 1.17 MB

1991

32

Positioning of proteins in membranes: A computational approach

Andrei L. Lomize, Irina D. Pogozheva, Mikhail A. Lomize, Henry I. Mosberg

Journal:

Protein Science

Year:

2006

Language:

english

File:

PDF, 508 KB

english, 2006

33

Centrally-administered opioid selective agonists inhibit drinking in the rat

Robert L. Spencer, David Deupree, Sigmund Hsiao, Henry I. Mosberg, Victor Hruby, Thomas F. Burks, Frank Porreca

Journal:

Pharmacology Biochemistry and Behavior

Year:

1986

Language:

english

File:

PDF, 595 KB

english, 1986

34

Thermodynamic parameters for [D-Pen2,5]enkephalin at δ-opioid receptors in the mouse isolated vas deferens

Robert B. Raffa, Kenneth D. Wild, Henry I. Mosberg, Frank Porreca

Journal:

European Journal of Pharmacology: Molecular Pharmacology

Year:

1993

Language:

english

File:

PDF, 629 KB

english, 1993

35

Conformationally restricted analogs of the direct thrombin inhibitor FM 19

Elizabeth A. Girnys, Vanessa R. Porter, Henry I. Mosberg

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 605 KB

english, 2011

36

Peptidic delta opioid receptor agonists produce antidepressant-like effects in the forced swim test and regulate BDNF mRNA expression in rats

Mary M. Torregrossa, Emily M. Jutkiewicz, Henry I. Mosberg, Gianfranco Balboni, Stanley J. Watson, James H. Woods

Journal:

Year:

2006

Language:

english

File:

PDF, 603 KB

english, 2006

37

Behavioral and neurobiological effects of the enkephalinase inhibitor RB101 relative to its antidepressant effects

Emily M. Jutkiewicz, Mary M. Torregrossa, Katarzyna Sobczyk-Kojiro, Henry I. Mosberg, John E. Folk, Kenner C. Rice, Stanley J. Watson, James H. Woods

Journal:

European Journal of Pharmacology

Year:

2006

Language:

english

File:

PDF, 316 KB

english, 2006

38

The effects of the phyllolitorin analogue [desTrp3,Leu8]phyllolitorin on scratching induced by bombesin and related peptides in rats

Mark D Johnson, Mei-Chuan Ko, Kevin S Choo, John R Traynor, Henry I Mosberg, Norah N Naughton, James H Woods

Journal:

Year:

1999

Language:

english

File:

PDF, 139 KB

english, 1999

39

Use of the Peptide Carrier System to Improve the Intestinal Absorption of L-α-Methyldopa: Carrier Kinetics, Intestinal Permeabilities, andIn VitroHydrolysis of Dipeptidyl Derivatives of L-α-Methyldopa

Ming Hu, Pullachipatti Subramanian, Henry I. Mosberg, Gordon L. Amidon

Journal:

Pharmaceutical Research

Year:

1989

File:

PDF, 776 KB

1989

40

SYNTHESIS, PHARMACOLOGICAL, CONFORMATIONAL, AND DYNAMIC STUDIES OF THE POTENT HORMONE ANTAGONISTS [1-PENICILLAMINE, 4-THREONINE]-OXYTOCIN AND [1-PENICILLAMINE, 2-PHENYLALANINE, 4-THREONINE] -OXYTOCIN : Conformational and Dynamic Considerations in the Design of Antagonists

VICTOR J. HRUBY, HENRY I. MOSBERG, MAC E. HADLEY, W. Y. CHAN, ANDREA M. POWELL

Journal:

Chemical Biology & Drug Design

Year:

1980

Language:

english

File:

PDF, 647 KB

english, 1980

41

1H n.m.r. investigation of conformational features of cyclic enkephalinamide analogs

Henry I. Mosberg, Peter W. Schiller

Journal:

Chemical Biology & Drug Design

Year:

1984

Language:

english

File:

PDF, 326 KB

english, 1984

42

1H-n.m.r. investigation of conformational features of cyclic, penicillamine-containing enkephalin analogs

HENRY I. MOSBERG

Journal:

Chemical Biology & Drug Design

Year:

1987

Language:

english

File:

PDF, 478 KB

english, 1987

43

Role of steric interactions in the delta opioid receptor selectivity of [d-Pen2, d-Pen5]enkephalin

HENRY I. MOSBERG, RONALD C. HAASETH, KONDAREDDIAR RAMALINGAM, ALFRED MANSOUR, HUDA AKIL, RONALD W. WOODARD

Journal:

Chemical Biology & Drug Design

Year:

1988

Language:

english

File:

PDF, 525 KB

english, 1988

44

Single residue modifications of the delta opioid receptor selective peptide, [d-Pen2,d-Pen5]-enkephalin (DPDPE) : Correlation of pharmacological effects with structural and conformational features

RONALD C. HAASETH, KATARZYNA SOBCZYK-KOJIRO, FEDOR MEDZIHRADSKY, CHARLES B. SMITH, HENRY I. MOSBERG

Journal:

Chemical Biology & Drug Design

Year:

1990

Language:

english

File:

PDF, 703 KB

english, 1990

45

Opioid receptor affinity and selectivity effects of second residue and carboxy terminal residue variation in a cyclic disulfide-containing opioid tetrapeptide

DEBORAH L. HEYL, JOHN R. OMNAAS, KATARZYNA SOBCZYK-KOJIRO, FEDOR MEDZIHRADSKY, CHARLES B. SMITH, HENRY I. MOSBERG

Journal:

Chemical Biology & Drug Design

Year:

1991

Language:

english

File:

PDF, 592 KB

english, 1991

46

Modification of the Phe3 aromatic moiety in delta receptor-selective dermorphin/deltorphin-related tetrapeptides Effects on opioid receptor binding

DEBORAH L. HEYL, HENRY I. MOSBERG

Journal:

Chemical Biology & Drug Design

Year:

1992

Language:

english

File:

PDF, 796 KB

english, 1992

47

Raman study of crystalline peptides containing β turns

Jay A. Fox, Anthony T. Tu, Victor J. Hruby, Henry I. Mosberg

Journal:

Archives of Biochemistry and Biophysics

Year:

1981

Language:

english

File:

PDF, 349 KB

english, 1981

48

[D-Pen2, L-cys5]enkephalinamide and [D-pen2, D-cys5]enkephalinamide, conformationally constrained cyclic enkephalinamide analogs with delta receptor specificity

Henry I. Mosberg, Robin Hurst, Victor J. Hruby, James J. Galligan, Thomas F. Burks, Kelvin Gee, Henry I. Yamamura

Journal:

Biochemical and Biophysical Research Communications

Year:

1982

Language:

english

File:

PDF, 449 KB

english, 1982

49

Opioid δ-receptor involvement in supraspinal and spinal antinociception in mice

Julius S. Heyman, Sheila A. Mulvaney, Henry I. Mosberg, Frank Porreca

Journal:

Year:

1987

Language:

english

File:

PDF, 684 KB

english, 1987

50

Modulation of μ-mediated antinociception by δ agonists in the mouse: selective potentiation of morphine and normorphine by [D-Pen2, D-Pen5]enkephalin

Julius S. Heyman, Jeffry L. Vaught, Henry I. Mosberg, Ronald C. Haaseth, Frank Porreca

Journal:

European Journal of Pharmacology

Year:

1989

Language:

english

File:

PDF, 733 KB

english, 1989